This website is made possible by generous donations from users like you. $18 helps keep JWA online for one day. Please consider making a gift before our June 30 fiscal year end. Thank you!

Close [x]

Show [+]

Gertrude Elion - Transplants and Antivirals - Gout

One of the trademarks of Elion's approach was the way she always used new compounds she synthesized as tools to find others. As she investigated the implications and metabolism of her drugs, she was often able to discover new and effective medications. Such was the case with her novel medication for gout. As she explored the metabolism of 6-MP in the effort to make its effects last longer, Burroughs Wellcome chemists created a compound that inhibited the enzyme that broke down the 6-MP. This new compound unfortunately did not prevent the negative side effects of 6-MP, but it did reduce the body's production of uric acid. Too much uric acid causes gout, which is not only extremely painful but can also be fatal. Given allopurinol, as the new compound was called, patients with gout watched their gouty deposits and the accompanying pain disappear with what seemed like miraculous suddenness.

0 Comments

Plain text

  • No HTML tags allowed.
  • Web page addresses and email addresses turn into links automatically.
  • Lines and paragraphs break automatically.

How to cite this page

Jewish Women's Archive. "Gertrude Elion - Transplants and Antivirals - Gout." (Viewed on June 20, 2019) <https://jwa.org/womenofvalor/elion/transplants-and-antivirals/gout>.

Donate

Help us elevate the voices of Jewish women.

donate now

The JWA Podcast

Can We Talk?

listen now

Get JWA in your inbox