Like many middle-class Jewish women at the turn of the twentieth century, Seraphine Eppstein Pisko used her experience in volunteer work to move into the realm of the professional workplace. As executive secretary and vice president of the National Jewish Hospital for Consumptives in Denver, Pisko was one of the first women to lead a national Jewish institution.

In the last decade of the nineteenth century, Jewish women shifted from benevolent work to social and personal reform, often through aiding immigrants and young, vulnerable women. They facilitated educational opportunities to learn about Jewish history and ethics, which in turn helped inform their aid work. These efforts created a space specifically for women in American Jewish society.